The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. Behavioural and supporting data are provided in the supplementary methods section.įunding: This study was supported by Canadian Institutes of Health Research,, to Sylvie Belleville Natural science and engineering research council of Canada (436140-2013) to Greg L West. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files. Received: AugAccepted: OctoPublished: December 6, 2017Ĭopyright: © 2017 West et al.

PLoS ONE 12(12):Įditor: Etsuro Ito, Waseda University, JAPAN (2017) Playing Super Mario 64 increases hippocampal grey matter in older adults.

In contrast, the CON group displayed significant grey matter loss in the hippocampus, cerebellum and the DLPFC.Ĭitation: West GL, Zendel BR, Konishi K, Benady-Chorney J, Bohbot VD, Peretz I, et al. Active control MUS training did, however, lead to a within-subject increase in the DLPFC, while both the VID and MUS training produced growth in the cerebellum. After training, a within-subject increase in grey matter within the hippocampus was significant only in the VID training group, replicating results observed in younger adults. Additionally, an active control group took a series of self-directed, computerized music (piano) lessons (MUS n = 12), while a no-contact control group did not engage in any intervention (CON n = 13). The video game experimental group (VID n = 8) engaged in a 3D-platform video game training over a period of 6 months. Older adults who were 55 to 75 years of age were randomized into three groups. In the current study, we tested the impact of 3D-platform video game training (i.e., Super Mario 64) on grey matter in the hippocampus, cerebellum, and the dorsolateral prefrontal cortex (DLPFC) of older adults. Playing 3D-platform video games has previously been shown to promote grey matter in the hippocampus in younger adults. Maintaining grey matter within the hippocampus is important for healthy cognition.

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